To make Sweet And Sour mixture, combine all the ingredients in a small pot. Heat the mixture over low heat, stirring constantly, until all the sugar is dissolved. Let it cool and keep in a fridge.
Rub the outer rim of a Margarita glass with a lime wedge and roll the wet edges in kosher salt spread on a plate. Fill the glass with large chunks of ice.
Combine all the Margarita ingredients in a Boston shaker with a cup of ice and shake until very cold. Strain the cocktail into the prepared glass and garnish the drink with a lime wheel.